Alumni,
Marjorie Dejoie-Brewer
Physician-scientist and senior Medical Affairs leader with 20+ years of hematology, Sickle Cell Disease, rare-disease, clinical research, and biopharmaceutical experience, including progressive leadership roles with Vertex Pharmaceuticals, Pfizer, Fulcrum Therapeutics, Children's Hospital of Philadelphia, and UnitedHealthcare.
Deep expertise translating complex hematology science, clinical evidence, patient insights, and healthcare-system dynamics into strategic Medical Affairs plans, evidence-generation priorities, scientific narratives, medical education, stakeholder engagement, and product lifecycle strategies.
Experienced in supporting pre-launch and launch readiness, including U.S. Medical Plan development, launch preparation, clinical-development strategy, evidence-generation planning, real-world evidence, scientific communications, medical materials, stakeholder engagement, patient access, and regulatory strategy. Contributed to the Vertex team that secured FDA approval of CASGEVY for Sickle Cell Disease.
Strategic and collaborative leader who operates effectively across Medical Affairs, Clinical Development, Research, Regulatory Affairs, Commercial, Market Access, HEOR, Safety, Government Affairs, MSL teams, advocacy organizations, academic institutions, and external scientific stakeholders. Recognized for executive-level communication, scientific credibility, matrix leadership, mentoring, stakeholder relationship development, and navigating complex, rapidly evolving environments.
Director of Patient Advocacy and Strategy
Fulcrum Therapeutics
Bridging the Gaps Graduation Year: 1993
University: University of Pennsylvania
Covenant House
Medicine,
Dr. Marjorie Dejoie Brewer is the owner of MAD Fit, a medical consulting and Wellness & Health business and currently holds the position of Medical Director of hemoglobinopathies in Global Medical Affairs and Global Strategist at Vertex Pharmaceuticals and Medical Director for the Sickle Cell Association of Delaware. She serves as Co-Chair of the Mental Health and Wellness initiative for the Sickle Cell Consortium, a medical consultant to SCDAA National, an ambassador to SICK cells and group leader for Meditation for Leadership. Prior to that she held the position of Director of Patient Advocacy for Global Product Development in Rare Disease at Pfizer and Clinical Research Outreach Liaison for Hydroxyurea and Transition at the Children’s Hospital of Philadelphia. Her groundbreaking work as a primary medical consultant for the Mayor’s “Fun, Fit, and Free” program, a key part of the Mayor’s Commission for Health, Fitness and inclusion, allowed her to apply her training in medicine, exercise physiology, and alternative medicine in an integrative, community based, preventative format with the primary goal of making Philadelphia a healthier city. From there, she molded a career in Functional Medicine, which utilizes a fusion of the principles of medicine, prescribed exercise, bio-psychosocial elements, stress reduction, nutrition, yoga and alternative medicine in the holistic treatment and care of patients with rare diseases and clients. Herself a patient of Sickle Cell Disease (SCD), Dr. Dejoie is a firm proponent and practitioner of comprehensive and preventative health and wellness planning. This became the mission behind her consulting firm “M.A.D. fit" established in 2002. Building on this foundation, Dr. Dejoie opened a wellness center, “Bonne Santé” in the fall of 2003, dedicating herself to making this world a better place by making it healthier, one person at a time
